Article
Arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in low-dose exposed mouse embryonic fibroblast cells
2018-03-14
Abstract excerpt
Epidemiological investigations have validated the positive relationships between arsenic in drinking water and several cancers, including skin, liver and lung cancers. Besides genotoxicity, arsenic exposure-related pathogenesis of disease is widely considered through epigenetic mechanisms; however, the underlying mechanistic insight remains elusive. Herein we explore the initial epigenetic changes via acute low-do...
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Identifiers and source
- Literature Corpus work
- fac48d6e-94d7-5fff-9427-7ad8e6179843
- DOI
- 10.1101/278424