Article

Rewired DEPTOR-mTORC1/2 signaling stabilizes cardiac fibroblast survival and activation

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>Cardiac fibroblasts (CFs) are resistant to stress-induced death, a property important for tissue repair but also central to pathological fibrosis and heart failure. Comparative transcriptomic and proteomic analyses identified the mTOR-interacting protein DEPTOR as selectively enriched in CFs. Although DEPTOR is widely characterized as an inhibitor of mTORC1 and mTORC2 in tumor and immor...

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Literature Corpus work: 517b56ce-a12e-5d7a-86c3-373c3f797a33
DOI: 10.21203/rs.3.rs-9081294/v1

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