Article

Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors

2023-09-08

Abstract excerpt

Cardiac fibrosis, a common pathophysiology associated with various heart diseases, occurs from the excess deposition of extracellular matrix (ECM) 1 . Cardiac fibroblasts (CFs) are the primary cells that produce, degrade, and remodel ECM during homeostasis and tissue repair 2 . Upon injury, CFs gain plasticity to differentiate into myofibroblasts 3 and adipocyte-like 4,5 and osteoblast-like 6 cells, promoting...

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Literature Corpus work: 89a2c11a-c17a-5c80-bd94-e2a0998738e6
DOI: 10.1101/2023.09.06.556593

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