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The orchestration of cell-cycle reentry and ribosome biogenesis network is critical for cardiac repair

1 Jan 2024

Abstract excerpt

The series signaling of circASXL1/CDK6/Rb1/cell-cycle reentry and circASXL1/Ncl/Ribo-bio/cytokinesis plays a crucial role in cardiac repair. UMSC-Exo effectively repairs infarcted myocardium by stimulating CM cell-cycle reentry and cytokinesis in a circASXL1-dependent manner. This study provides innovative therapeutic strategies targeting the circASXL1 signaling network for MI and offering potential avenues for...

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PMID: 38994017
DOI: 10.7150/thno.96460

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