Article

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling

2020-12-01

Abstract excerpt

The mechanistic target of rapamycin (mTOR) is a key regulator of pathological remodeling in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in cardiomyocytes is protective, however, a detailed role of mTOR in translational regulation of specific mRNA networks in the diseased heart is largely unknown. A cardiomyocyte genome-wide sequencing approach was used to define mTOR-depen...

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Literature Corpus work: 2b6ed603-fdec-530e-9fb9-11502a49a727
DOI: 10.1101/2020.11.29.403196

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