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Article

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

Molecular cell - 21 Oct 2011

Zhao Yongchao, Xiong Xiufang, Sun Yi

Abstract excerpt

DEPTOR, an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase. Here we report that DEPTOR is a physiological substrate of SCF(βTrCP) E3 ligase for targeted degradation. Upon growth factor stimulation, RSK1 and S6K1 kinases are activated to phosphorylate DEPTOR, which is then recognized by the F box protein, βTrCP, via its degron sequence for subsequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-akt

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Ribosomal Protein S6 Kinases, 90-kDa

Share to TOR Serine-Threonine Kinases

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Source

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Identifiers

PMID: 22017876
DOI: 10.1016/j.molcel.2011.08.029
PMCID: PMC3216641

Genes

DEPTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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