Article

Pathogenic potential of Hic1 expressing cardiac stromal progenitors

2019-02-08

Abstract excerpt

The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are still poorly understood. Here, we identify heart-resident PDGFRa + Sca-1 + cells as cardiac Fibro/Adipogenic Progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2141b238-2068-53cd-8a8c-2989783dd90b
DOI: 10.1101/544403

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenic potential of Hic1 expressing cardiac stromal progenitorsDOI 10.1101/544403Read

Cell Specific Reactivation of Epicardium at the Origin of Fibro-Fatty Remodeling of the Atrial MyocardiumSemantic proximity Read

Tissue-resident Sca1+ PDGFRα+ mesenchymal progenitors are the cellular source of fibrofatty infiltration in arrhythmogenic cardiomyopathySemantic proximity Read

Pathogenic Potential of Hic1-Expressing Cardiac Stromal ProgenitorsSemantic proximity Read

Adventitial leptin receptor-expressing fibroblasts are preferential contributors to fibrotic remodeling of the heart post infarctionSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

Origins of Cardiac FibroblastsSemantic proximity Read

Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and ChallengesSemantic proximity Read

Stem cell antigen-1 cell-derived fibroblasts are crucial for cardiac fibrosis during heart failureSemantic proximity Read

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read

Cardiomyocytes Undergo a Mesenchymal-Like Fate Transition in Myocardial FibrosisSemantic proximity Read

Diverse origins and activation of fibroblasts in cardiac fibrosisSemantic proximity Read

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read