Article

ER Calcium Depletion as a Key Driver for Impaired ER-to-Mitochondria Calcium Transfer and Mitochondrial Dysfunction in Wolfram Syndrome

2023-10-13

Abstract excerpt

<title>Abstract</title> Wolfram syndrome (WS) is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in WS involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, performed in primary isolated neurons, the most affected and disease-relevant cells, involving both WS genes, explains how the disturbed ER Ca2+...

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Literature Corpus work: 160b8c86-a797-5ddd-a654-051395cbf5d6
DOI: 10.21203/rs.3.rs-3385750/v1

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