Article

Bcl-2 suppresses ER-mitochondrial Ca2+ transfer by directly limiting ER-mitochondrial contact sites

2026-08-13

Abstract excerpt

<title>Abstract</title> <p> Anti-apoptotic B cell lymphoma (Bcl-2) tightly regulates apoptosis by controlling mitochondrial outer membrane permeabilization and intracellular Ca <sup>2+</sup> dynamics. At the endoplasmic reticulum (ER), Bcl-2 directly inhibits inositol 1,4,5-trisphosphate receptors (IP <sub>3</sub> Rs), intracellular Ca <sup>2+</sup> -release channels, thereby limiting mitochondrial Ca <su...

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Literature Corpus work: 442fc165-47f7-5b07-94ef-3364b8838cf7
DOI: 10.21203/rs.3.rs-10449449/v1

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