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Article

Activation of podocyte Notch mediates early Wt1 glomerulopathy

3 Feb 2018

Abstract excerpt

The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of scar tissue within glomeruli, the mechanisms of which are poorly understood. Here, we used a tamoxifen-based CRE-LoxP system to induce deletion of Wt1 in adult...

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Identifiers

PMID: 29398135
DOI: 10.1016/j.kint.2017.11.014

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Activation of podocyte Notch mediates early Wt1 glomerulopathyPMID 29398135Read ↗

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