Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

Kidney international - 1 Aug 2015

Lefebvre Jonathan, Clarkson Michael, Massa Filippo, Bradford Stephen T, Charlet Aurelie, Buske Fabian, Lacas-Gervais Sandra, Schulz Herbert, Gimpel Charlotte, Hata Yutaka, Schaefer Franz, Schedl Andreas

Abstract excerpt

The Wilms' tumor suppressor WT1 is a key regulator of podocyte function that is mutated in Denys-Drash and Frasier syndromes. Here we have used an integrative approach employing ChIP, exon array, and genetic analyses in mice to address general and isoform-specific functions of WT1 in podocyte differentiation. Analysis of ChIP-Seq data showed that almost half of the podocyte-specific genes are direct targets of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Guanylate Kinases
Share to Glomerulosclerosis, Focal Segmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alternative Splicing

Share to Forkhead Transcription Factors

Share to Glomerulonephritis, Membranoproliferative

Share to Lipopolysaccharides

Share to Podocytes

Share to WT1 Proteins

Source

Identifiers

PMID: 25993318
DOI: 10.1038/ki.2015.140

Genes

MAGI2
FOXC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.PMID 25993318Read ↗

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms’ Tumor 1 Target Genes in Podocyte Differentiation and MaintenanceSemantic proximity Read ↗

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

New insights into the function of the Wilms tumor suppressor geneWT1in podocytesSemantic proximity Read ↗

Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read ↗

Clinical Aspects of WT1 and the Kidney.Semantic proximity Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.Semantic proximity Read ↗

Wilms' Tumor Suppressor Gene WT1Semantic proximity Read ↗

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.Semantic proximity Read ↗

WT1 targetsGas1to maintain nephron progenitor cells by modulating FGF signalsSemantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.