Article

Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung Adenocarcinoma

2023-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Non-Small Cell Lung Cancer (NSCLC) patients are diagnosed late when the disease has metastasized. Kras is a prevalent mutation in NSCLC besides EGFR and TP53 and targeted therapies against this have been challenging. We have explored deregulation of an endocytic adapter protein, Huntingtin Interacting Protein-1(HIP1) and its relevance in a Kras mutant lung adenocarcinoma cell line as a model s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 515899f6-e128-51c7-b52b-cef6572255c3
DOI: 10.1101/2023.03.27.534427

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung AdenocarcinomaDOI 10.1101/2023.03.27.534427Read

HIP1: trafficking roles and regulation of tumorigenesis.Semantic proximity Read

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cellsSemantic proximity Read

TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulationSemantic proximity Read

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolismSemantic proximity Read

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinomaSemantic proximity Read

Hexokinase 1b is a novel target for Non–small-cell lung cancerSemantic proximity Read

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.Semantic proximity Read

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read

Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD).Semantic proximity Read

Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilizationSemantic proximity Read

HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.Semantic proximity Read

HIP1 mediates oncogenic transformation and cancer progression through STAT3 signallingSemantic proximity Read