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Article

HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.

Journal of experimental & clinical cancer research : CR - 30 Sept 2024

Geng Pengyu, Ye Fei, Dou Peng, Hu Chunxiu, He Jiarui, Zhao Jinhui, Li Qi, Bao Miao, Li Xiangnan, Liu Xinyu, Xu Guowang

Abstract excerpt

BACKGROUND: The mutations of oncogenic epidermal growth factor receptor (EGFR) is an important cause of lung adenocarcinoma (LUAD) malignance. It has been knowm that metabolic reprogramming is an important hallmark of malignant tumors, and purine metabolism is a key metabolic pathway for tumor progression and drug resistance, but its relationship with the EGFR-mutant LUAD is unclear. METHODS: Metabolic...

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Identifiers

PMID: 39343971
DOI: 10.1186/s13046-024-03184-8
PMCID: PMC11441087

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