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Article

Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.

Neurobiology of disease - 1 May 2015

Kalume Franck, Oakley John C, Westenbroek Ruth E, Gile Jennifer, de la Iglesia Horacio O, Scheuer Todd, Catterall William A

Abstract excerpt

Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel NaV1.1. Our mouse genetic model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanism is unknown. Electroencephalographic studies revealed abnormal sleep in DS mice, including reduced delta wave power, reduced sleep spindles, increased brief wakes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25766678
DOI: 10.1016/j.nbd.2015.02.016
PMCID: PMC4402280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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