Article

Disruption of Prostaglandin F <sub>2α</sub> Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis

2023-06-07

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a chronic parenchymal lung disease characterized by repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix deposition for which unmet need persists for effective therapeutics. The bioactive eicosanoid, prostaglandin F2 α , and its cognate receptor FPr ( Ptfgr ) are implicated as a TGF β 1 independent signaling hub for IPF. To asses...

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Literature Corpus work: 5100e649-ca61-5cfb-8340-678d16cabfe2
DOI: 10.1101/2023.06.07.543956

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Disruption of Prostaglandin F <sub>2α</sub> Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary FibrosisDOI 10.1101/2023.06.07.543956Read

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