Article
Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis.
The American journal of pathology - 1 May 2014
Xia Hong, Bodempudi Vidya, Benyumov Alexey, Hergert Polla, Tank Damien, Herrera Jeremy, Braziunas Jeff, Larsson Ola, Parker Matthew, Rossi Daniel, Smith Karen, Peterson Mark, Limper Andrew, Jessurun Jose, Connett John, Ingbar David, Phan Sem, Bitterman Peter B, Henke Craig A
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly with a prevalence of one million persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli, creating a reticular network that leads to death by asphyxiation. Lung fibroblasts from patients with IPF have phenotypic hallmarks, distinguishing them from their normal counterparts: pathologically...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.