Article

Severe myelosuppression and alopecia with thiopurine initiation and NUDT15 deficiency

2024-11-21

Abstract excerpt

Thiopurines are a class of immunosuppressant and anti-neoplastic agents. They are widely used in the treatment of inflammatory bowel disease, hematological malignancies, and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines even at tenfold dose reductions. We present a case of thiopurine...

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Literature Corpus work: 50d42969-bc1a-5c7e-b66e-9c50de820b73
DOI: 10.22541/au.173216899.94908934/v1

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