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Article

Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15.

Human genomics - 4 Apr 2026

Zhou Yitian, Lauschke Lukas M, Lauschke Volker M

Abstract excerpt

Thiopurine medications are widely used for the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. However, thiopurine-induced hemotoxicity occurs in up to 30% of patients, which causes substantial morbidity and limits therapeutic success. These adverse effects are associated with genetic variation in TPMT and NUDT15, which encode key enzymes involved in thiopurine metabolism. While the...

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Source

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Identifiers

PMID: 41935317
DOI: 10.1186/s40246-026-00959-2
PMCID: PMC13069803

Genes

NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15.PMID 41935317Read ↗

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update.Semantic proximity Read ↗

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