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Article

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose.

Oncotarget - 21 Feb 2017

Yin Dandan, Xia Xuyang, Zhang Junlong, Zhang Shouyue, Liao Fei, Zhang Ge, Zhang Yan, Hou Qianqian, Yang Xue, Wang Hong, Ma Zhigui, Wang Heyao, Zhu Yiping, Zhang Wei, Wang Yuelan, Liu Bo, Wang Lanlan, Xu Heng, Shu Yang

Abstract excerpt

Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity susceptibility (1752 patients from 7 independent cohorts), as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28088792
DOI: 10.18632/oncotarget.14594
PMCID: PMC5355121

Genes

NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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