Article
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.
Nature chemical biology - 1 May 2011
Xu Jie, Reumers Joke, Couceiro José R, De Smet Frederik, Gallardo Rodrigo, Rudyak Stanislav, Cornelis Ann, Rozenski Jef, Zwolinska Aleksandra, Marine Jean-Christophe, Lambrechts Diether, Suh Young-Ah, Rousseau Frederic, Schymkowitz Joost
Abstract excerpt
Many p53 missense mutations possess dominant-negative activity and oncogenic gain of function. We report that for structurally destabilized p53 mutants, these effects result from mutant-induced coaggregation of wild-type p53 and its paralogs p63 and p73, thereby also inducing a heat-shock response. Aggregation of mutant p53 resulted from self-assembly of a conserved aggregation-nucleating sequence within the...
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