Article
The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
Biochemistry - 23 Jun 2015
Herzog Gal, Shmueli Merav D, Levy Limor, Engel Liat, Gazit Ehud, Klärner Frank-Gerrit, Schrader Thomas, Bitan Gal, Segal Daniel
Abstract excerpt
The tumor suppressor p53 plays a unique role as a central hub of numerous cell proliferation and apoptotic pathways, and its malfunction due to mutations is a major cause of various malignancies. Therefore, it serves as an attractive target for developing novel anticancer therapeutics. Because of its intrinsically unstable DNA binding domain, p53 unfolds rapidly at physiological temperature. Certain mutants shift...
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