Genetic inhibition of CARD9 accelerates the development of experimental atherosclerosis through CD36 dependent-defective autophagy

Abstract excerpt

<title>Abstract</title> <p> Macrophage-mediated innate immune responses contribute to the initiation, progression and complications of atherosclerosis. However, the underlying pathways linking activation of macrophages to atherosclerotic plaque develoment are still poorly understood. We hypothesized that activation of caspase recruitment-domain containing protein 9 (CARD9) plays a determinant role in pro-atherog...

Topics

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• Apolipoproteins E
• Atherosclerosis
• Cell Line
• Macrophage Activation
• Macrophages
• Mice, Inbred C57BL
• NF-kappa B
• Toll-Like Receptor 9

Identifiers and source

Literature Corpus work

09cdbe9c-d8df-559c-9dc1-7a6e8847be81

DOI

10.21203/rs.3.rs-1834549/v2