Article

Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor

2023-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Patient symptom relief is often heavily influenced by the residence time of the inhibitor-target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodylator used in conditions such as asthma or chronic obstructive pulmonary disease (COPD). The mechanistic insights of this inhibitor remain unclear, specifically, elucidation of the main factors determining the u...

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Literature Corpus work: 5098863e-3191-5141-af1f-280dc3e68c63
DOI: 10.1101/2023.01.03.522558

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