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Article

The predicted 3D structures of the human M1 muscarinic acetylcholine receptor with agonist or antagonist bound.

ChemMedChem - 1 Aug 2006

Peng Joyce Yao-chun, Vaidehi Nagarajan, Hall Spencer E, Goddard William A

Abstract excerpt

The muscarinic acetylcholine G-protein-coupled receptors are implicated in diseases ranging from cognitive dysfunctions to smooth-muscle disorders. To provide a structural basis for drug design, we used the MembStruk computational method to predict the 3D structure of the human M1 muscarinic receptor. We validated this structure by using the HierDock method to predict the binding sites for three agonists and four...

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Identifiers

PMID: 16902941
DOI: 10.1002/cmdc.200600047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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