Article

Kinetic Machine Learning Unravels Ligand-Directed Conformational Change of μ Opioid Receptor

2017-07-31

Abstract excerpt

<h4>ABSTRACT</h4> The μ Opioid Receptor (μOR) is a G-Protein Coupled Receptor (GPCR) that mediates pain and is a key target for clinically administered analgesics. The current generation of prescribed opiates – drugs that bind to μOR – engender dangerous side effects such as respiratory depression and addiction in part by stabilizing off-target conformations of the receptor. To determine both the key conformation...

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Literature Corpus work: 9231418d-f1ee-570a-a414-7a6de626cb1e
DOI: 10.1101/170886

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