Article

Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutations

2018-04-20

Abstract excerpt

Ran ( Ra s-related n uclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other diverse functions in the cytoplasm, as well as in cellular transformation when activated. Unlike other Ras superfamily proteins, Ran contains an auto-inhibitory C-terminal tail, which packs against its G domain and bias Ran toward...

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Literature Corpus work: 5084c1be-2e86-5aa7-af8e-b4ee026f2adf
DOI: 10.1101/305177

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