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Article

Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype.

International journal of molecular sciences - 4 Feb 2023

El-Tanani Mohamed, Nsairat Hamdi, Mishra Vijay, Mishra Yachana, Aljabali Alaa A A, Serrano-Aroca Ángel, Tambuwala Murtaza M

Abstract excerpt

Ran is a member of the Ras superfamily of proteins, which primarily regulates nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and nuclear envelope (NE) reassembly. Therefore, Ran is an integral cell fate determinant. It has been demonstrated that aberrant Ran expression in cancer is a result of upstream dysregulation of the expression of various factors, such as osteopontin...

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Identifiers

PMID: 36834476
DOI: 10.3390/ijms24043065
PMCID: PMC9968026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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