Article

Identification of a new inhibitor of Ran GTPase with potential therapeutic value in epithelial ovarian cancer

2025-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Compiled research studies suggest that the small GTPase Ran is critical in cancer initiation and progression. Compounds that block Ran activity would be valuable for cancer treatment. Yet, to date, there is no inhibitor proven to be efficient and specific to Ran. Here, by learning lessons from the discovery of KRAS G12C inhibitors, we generated a structural model of the switch II pocket of GDP-b...

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Literature Corpus work: d4e1c9dd-a775-522d-88f3-44fbf65834eb
DOI: 10.1101/2025.03.02.641080

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