Article
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.
Nature metabolism - 1 Feb 2021
Huang Lam O, Rauch Alexander, Mazzaferro Eugenia, Preuss Michael, Carobbio Stefania, Bayrak Cigdem S, Chami Nathalie, Wang Zhe, Schick Ursula M, Yang Nancy, Itan Yuval, Vidal-Puig Antonio, den Hoed Marcel, Mandrup Susanne, Kilpeläinen Tuomas O, Loos Ruth J F
Abstract excerpt
Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The mechanisms that uncouple adiposity from its cardiometabolic complications are not fully understood. Here, we identify 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk....
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