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Article

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

Nature communications - 14 Sept 2024

DeForest Natalie, Wang Yuqi, Zhu Zhiyi, Dron Jacqueline S, Koesterer Ryan, Natarajan Pradeep, Flannick Jason, Amariuta Tiffany, Peloso Gina M, Majithia Amit R

Abstract excerpt

Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological studies. To discover novel insulin resistance genes in the general population, we conducted genome-wide association studies in 382,129 individuals for triglyceride to HDL-cholesterol ratio (TG/HDL), a surrogate marker of insulin...

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Share to Cholesterol, HDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 39277575
DOI: 10.1038/s41467-024-52105-y
PMCID: PMC11401929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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