Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

doi:10.1038/ng.3714

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Article

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

Nature genetics - 1 Jan 2017

Lotta Luca A, Gulati Pawan, Day Felix R, Payne Felicity, Ongen Halit, van de Bunt Martijn, Gaulton Kyle J, Eicher John D, Sharp Stephen J, Luan Jian'an, De Lucia Rolfe Emanuella, Stewart Isobel D, Wheeler Eleanor, Willems Sara M, Adams Claire, Yaghootkar Hanieh, Forouhi Nita G, Khaw Kay-Tee, Johnson Andrew D, Semple Robert K, Frayling Timothy, Perry John R B, Dermitzakis Emmanouil, McCarthy Mark I, Barroso Inês, Wareham Nicholas J, Savage David B, Langenberg Claudia, O'Rahilly Stephen, Scott Robert A

Abstract excerpt

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link with higher...

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PMID: 27841877
DOI: 10.1038/ng.3714
PMCID: PMC5774584

Genes

CCDC92
DNAH10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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