Back to search

Article

Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in <i>Clostridioides difficile</i>

2025-11-06

Abstract excerpt

Clostridioides difficile is an important nosocomial pathogen that has been classified as an “urgent threat” by the CDC. Antibiotic use is the primary risk factor for the development of C. difficile -associated disease because it disrupts healthy protective gut flora and enables C. difficile to colonize the colon. C. difficile damages host tissue by secreting toxins and disseminates by forming spores. Nutrient a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8e939451-655b-57fb-8012-2b2487c16bc2
DOI
10.1101/2025.11.06.687015
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in <i>Clostridioides difficile</i>DOI 10.1101/2025.11.06.687015
Repression of <i>Clostridium difficile</i> toxin gene expression by CodYSemantic proximity
Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains TCH1516 and LACSemantic proximity
Elucidating the CodY regulon in <i>Staphylococcus aureus</i> USA300 substrainsSemantic proximity
Phase-variable expression of pdcB, a phosphodiesterase, influences sporulation in Clostridioides difficile.Semantic proximity
RstA is a Major Regulator of <i>Clostridioides difficile</i> Toxin Production and MotilitySemantic proximity
Characterization of a β-lactamase that contributes to intrinsic β-lactam resistance in <i>Clostridioides difficile</i>Semantic proximity
CodY is a global regulator of virulence-associated properties for Clostridium perfringens type D strain CN3718.Semantic proximity
An RNA-centric global view of <i>Clostridioides difficile</i> reveals broad activity of Hfq in a clinically important Gram-positive bacteriumSemantic proximity
The CodY regulator is essential for virulence in Streptococcus suis serotype 2.Semantic proximity
Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291.Semantic proximity
Strain variation in <i>Clostridioides difficile</i> toxin activity associated with genomic variation at both PaLoc and non-PaLoc lociSemantic proximity
CodY Is a Global Transcriptional Regulator Required for Virulence in Group B StreptococcusSemantic proximity
Select a neighboring publication to make it the new centre.