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TcdC Does Not Significantly Repress Toxin Expression in Clostridium difficile 630ΔErm

17 Aug 2012

Abstract excerpt

In the past decade, Clostridium difficile has emerged as an important gut pathogen. Symptoms of C. difficile infection range from mild diarrhea to pseudomembranous colitis, sometimes resulting in colectomy or death. The main virulence factors of C. difficile are toxin A and toxin B. Besides the genes encoding these toxins (tcdA and tcdB), the pathogenicity locus (PaLoc) also contains genes encoding a sigma factor...

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PMID: 22912837
DOI: 10.1371/journal.pone.0043247

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