Article

Production of a synthetic superenhancer to monitor SOX2 transcriptional activity in glioblastoma

2021-01-01

Abstract excerpt

Glioblastoma (GBM) is the most common adult brain cancer and one of the most lethal human cancers. SOX2-expressing GBM cells drive tumour growth and have a neural stem cell-like identity. Here, we developed novel synthetic superenhancers that inform some of the gene regulatory circuits operating in GBM stem cells (GSCs). Individual SOX2 enhancers that are active within the GSC, but not in their differentiated prog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5029ecd3-6570-53d6-bbb3-cd644df9f7e2
DOI: 10.7488/era/1349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Production of a synthetic superenhancer to monitor SOX2 transcriptional activity in glioblastomaDOI 10.7488/era/1349Read

A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor developmentSemantic proximity Read

The functional genomic circuitry of human glioblastoma stem cellsSemantic proximity Read

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysisSemantic proximity Read

Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2Semantic proximity Read

<i>CASCADES</i> , a novel <i>SOX2</i> super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiformeSemantic proximity Read

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastomaSemantic proximity Read

Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.Semantic proximity Read

SOX21 Suppresses Glioblastoma Growth by Repressing AP-1 ActivitySemantic proximity Read

Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinomaSemantic proximity Read

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem CellsSemantic proximity Read

Development of a Sox2 reporter system modeling cellular heterogeneity in gliomaSemantic proximity Read

A flexible repertoire of transcription factor binding sites and diversity threshold determines enhancer activity in embryonic stem cellsSemantic proximity Read