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Development of a Sox2 reporter system modeling cellular heterogeneity in glioma

21 Nov 2014

Abstract excerpt

BACKGROUND: Malignant gliomas are complex systems containing a number of factors that drive tumor initiation and progression, including genetic aberrations that lead to extensive cellular heterogeneity within the neoplastic compartment. Mouse models recapitulate these genetic aberrations, but readily observable heterogeneity remains challenging. METHODS: To interrogate cellular heterogeneity in mouse glioma...

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PMID: 25416826
DOI: 10.1093/neuonc/nou320

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