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Article

Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.

PloS one - 1 Jan 2011

Alonso Marta M, Diez-Valle Ricardo, Manterola Lorea, Rubio Angel, Liu Dan, Cortes-Santiago Nahir, Urquiza Leire, Jauregi Patricia, Lopez de Munain Adolfo, Sampron Nicolás, Aramburu Ander, Tejada-Solís Sonia, Vicente Carmen, Odero María D, Bandrés Eva, García-Foncillas Jesús, Idoate Miguel A, Lang Frederick F, Fueyo Juan, Gomez-Manzano Candelaria

Abstract excerpt

We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor. We initially looked for unbalanced genomic rearrangements in the Sox2 locus in 42 GBM samples and found that So...

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Identifiers

PMID: 22069467
DOI: 10.1371/journal.pone.0026740
PMCID: PMC3206066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22069467-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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