Article

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

2026-07-27

Abstract excerpt

APECED (Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy) is a rare syndrome of multi-organ autoimmunity driven by the presence of self-reactive T cells and autoantibodies caused by mutations in the gene Autoimmune regulator ( AIRE ). Compared to the well-defined role of AIRE in establishing and maintaining T cell central tolerance, less is known about how AIRE deficiency impacts B cell phenotypes t...

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Literature Corpus work: 50261209-f399-53ab-b9a6-4675c86f1e22
DOI: 10.64898/2026.07.24.740518

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