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A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases

1 Jan 2022

Abstract excerpt

Chronic and debilitating autoimmune sequelae pose a grave concern for the post-COVID-19 pandemic era. Based on our discovery that the glycosaminoglycan dermatan sulfate (DS) displays peculiar affinity to apoptotic cells and autoantigens (autoAgs) and that DS-autoAg complexes cooperatively stimulate autoreactive B1 cell responses, we compiled a database of 751 candidate autoAgs from six human cell types. At least...

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PMID: 35237749
DOI: 10.1016/j.jtauto.2022.100147

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