Article
REAP: A platform to identify autoantibodies that target the human exoproteome
2021-02-12
Abstract excerpt
Autoantibodies that recognize extracellular proteins (the “exoproteome”) exert potent biological effects but have proven challenging to detect with existing screening technologies. Here, we developed Rapid Extracellular Antigen Profiling (REAP) as a technique for comprehensive, high-throughput discovery of exoproteome-targeting autoantibodies. With REAP, patient samples are applied to a genetically-barcoded librar...
Topics
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- Adrenal Hormones and Disorders
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Animal Virus Infections Studies
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
Identifiers and source
- Literature Corpus work
- a4cf711d-6f3d-5269-87e5-7f600ae453e7
- DOI
- 10.1101/2021.02.11.430703