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Article

Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1

1 Feb 2016

Abstract excerpt

Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands of peripheral tissue antigens in a process critical for establishing central immune tolerance. We here used proteome arrays to perform a comprehensive study of autoimmune...

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PMID: 26830021
DOI: 10.1038/srep20104

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