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Article

Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.

International reviews of immunology - 1 Oct 2012

Capalbo Donatella, Giardino Giuliana, Martino Lucia De, Palamaro Loredana, Romano Rosa, Gallo Vera, Cirillo Emilia, Salerno Mariacarolina, Pignata Claudio

Abstract excerpt

The thymus is a specialized organ that provides an inductive environment for the development of T cells from multipotent hematopoietic progenitors. Self-nonself discrimination plays a key role in inducing a productive immunity and in preventing autoimmune reactions. Tolerance represents a state of immunologic nonresponsiveness in the presence of a particular antigen. The immune system becomes tolerant to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23083345
DOI: 10.3109/08830185.2012.697230

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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