Article

A Master Autoantigen-ome Links Alternative Splicing, Female Predilection, and COVID-19 to Autoimmune Diseases

2021-08-04

Abstract excerpt

Chronic and debilitating autoimmune sequelae pose a grave concern for the post-COVID-19 pandemic era. Based on our discovery that the glycosaminoglycan dermatan sulfate (DS) displays peculiar affinity to apoptotic cells and autoantigens (autoAgs) and that DS-autoAg complexes cooperatively stimulate autoreactive B1 cell responses, we compiled a database of 751 candidate autoAgs from six human cell types. At least 6...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cff01d3-b7a4-58e6-80ff-a95d770f9459
DOI: 10.1101/2021.07.30.454526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Master Autoantigen-ome Links Alternative Splicing, Female Predilection, and COVID-19 to Autoimmune DiseasesDOI 10.1101/2021.07.30.454526Read

A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseasesSemantic proximity Read

An Autoantigen-ome from HS-Sultan B-Lymphoblasts Offers a Molecular Map for Investigating Autoimmune Sequelae of COVID-19Semantic proximity Read

An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19Semantic proximity Read

An Autoantigen Profile of Human A549 Lung Cells Reveals Viral and Host Etiologic Molecular Attributes of Autoimmunity in COVID-19Semantic proximity Read

Proteomic approaches for biomarker discovery and clinical applications in autoimmune diseasesSemantic proximity Read

Human Autoantigen Atlas: Searching for the Hallmarks of AutoantigensSemantic proximity Read

Host Genetics at the Intersection of Autoimmunity and COVID-19: A Potential Key for Heterogeneous COVID-19 Severity.Semantic proximity Read

Diverse Functional Autoantibodies in Patients with COVID-19Semantic proximity Read

Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.Semantic proximity Read

Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen yearsSemantic proximity Read

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsetsSemantic proximity Read

Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture.Semantic proximity Read