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Article

IL-22 Paucity in APECED Is Associated With Mucosal and Microbial Alterations in Oral Cavity.

Frontiers in immunology - 1 Jan 2020

Kaleviste Epp, Rühlemann Malte, Kärner Jaanika, Haljasmägi Liis, Tserel Liina, Org Elin, Trebušak Podkrajšek Katarina, Battelino Tadej, Bang Corinna, Franke Andre, Peterson Pärt, Kisand Kai

Abstract excerpt

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by recessive mutations in the AIRE gene. The hallmark of the disease is the production of highly neutralizing autoantibodies against type I interferons and IL-22. Considering the importance of IL-22 in maintaining mucosal barrier integrity and shaping its microbial community, we sought to study potential changes in the oral cavity...

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Identifiers

PMID: 32477345
DOI: 10.3389/fimmu.2020.00838
PMCID: PMC7232598

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