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<i>De novo</i> germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

2021-01-04

Abstract excerpt

Here we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/Nck H (high T1D incidence) and NOD/Nck L (low T1D incidence) revealed the presence of a limited number of variants specific to each subline. Treating the age of T1D onset as a quantitative t...

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Identifiers and source

Literature Corpus work
50230e71-c166-57b2-bca9-827d16061124
DOI
10.1101/2020.12.30.424747
Open publication

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<i>De novo</i> germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) miceDOI 10.1101/2020.12.30.424747
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