Article
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice.
Disease models & mechanisms - 1 Jun 2022
Chatenoud Lucienne, Marquet Cindy, Valette Fabrice, Scott Lindsay, Quan Jiexia, Bu Chun Hui, Hildebrand Sara, Moresco Eva Marie Y, Bach Jean-François, Beutler Bruce
Abstract excerpt
Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci that affect disease risk. Here, we created random germline mutations in NOD/NckH mice and used automated meiotic mapping to identify mutations modifying T1D incidence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.