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African Green Monkeys Respond to Synthetic Aβ Oligomers with Persistent Alzheimer’s-like Activation

2025-10-08

Abstract excerpt

<h4>SUMMARY</h4> Wild African green monkeys (AGMs) provide a promising alternative to congenic rodent models because of their closer evolutionary relationship to humans and natural genetic variation. They share key physiological and biochemical traits with humans, including lifespan, neuroanatomy, vascular structure, and inflammatory responses. Unlike rodents, AGMs naturally develop Alzheimer’s-like amyloid-β (Aβ...

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Literature Corpus work
4ff1ce55-9a13-51c1-a54d-1490a370ff47
DOI
10.1101/2025.10.08.678256
Open publication

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African Green Monkeys Respond to Synthetic Aβ Oligomers with Persistent Alzheimer’s-like ActivationDOI 10.1101/2025.10.08.678256
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