Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2021

Beckman Danielle, Chakrabarty Paramita, Ott Sean, Dao Amanda, Zhou Eric, Janssen William G, Donis-Cox Kristine, Muller Scott, Kordower Jeffrey H, Morrison John H

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a devastating condition with no effective treatments, with promising findings in rodents failing to translate into successful therapies for patients. METHODS: Targeting the vulnerable entorhinal cortex (ERC), rhesus monkeys received two injections of an adeno-associated virus expressing a double tau mutation (AAV-P301L/S320F) in the left hemisphere, and control AAV-green...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Disease Models, Animal

Share to Entorhinal Cortex

Share to Macaca mulatta

Share to Microglia

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33734581
DOI: 10.1002/alz.12318
PMCID: PMC8252011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.PMID 33734581Read ↗

Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.Semantic proximity Read ↗

A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tauSemantic proximity Read ↗

A non-human primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tauSemantic proximity Read ↗

Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsSemantic proximity Read ↗

Non human primate models for Alzheimer’s disease-related research and drug discoverySemantic proximity Read ↗

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's DiseaseSemantic proximity Read ↗

Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infectionSemantic proximity Read ↗

Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse modelSemantic proximity Read ↗

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathySemantic proximity Read ↗

Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice.Semantic proximity Read ↗

African Green Monkeys Respond to Synthetic Aβ Oligomers with Persistent Alzheimer’s-like ActivationSemantic proximity Read ↗

Tau-Targeting Nanoparticles for Treatment of Alzheimer's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.