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Article

Early blood immune molecular alterations in cynomolgus monkeys with a PSEN1 mutation causing familial Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2024

Li Mengqi, Guan Mingfeng, Lin Jianbang, Zhu Kaichuan, Zhu Jiayi, Guo Ming, Li Yinhu, Chen Yefei, Chen Yijing, Zou Ying, Wu Daiqiang, Xu Junxin, Yi Wanying, Fan Yingying, Ma Shuangshuang, Chen Yuewen, Xu Jun, Yang Lixin, Dai Ji, Ye Tao, Lu Zhonghua, Chen Yu

Abstract excerpt

INTRODUCTION: More robust non-human primate models of Alzheimer's disease (AD) will provide new opportunities to better understand the pathogenesis and progression of AD. METHODS: We designed a CRISPR/Cas9 system to achieve precise genomic deletion of exon 9 in cynomolgus monkeys using two guide RNAs targeting the 3' and 5' intron sequences of PSEN1 exon 9. We performed biochemical, transcriptome, proteome, and...

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PMID: 38973166
DOI: 10.1002/alz.14046
PMCID: PMC11350033

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