Back to search

Article

Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice

2026-02-27

Abstract excerpt

Visual dysfunction and retinal structural alterations often precede brain pathology and cognitive decline in Alzheimer’s disease (AD), yet the molecular basis of these early changes and their relationship to the brain pathology remain unclear. Here, we performed quantitative proteomic profiling of retina and brain from 1-month of age triple-transgenic (3xTg-AD) mice harboring human PS1 M146V , APP Swe , and tau...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
747f7299-a452-5407-9c9f-3ea80deb41e8
DOI
10.64898/2026.02.26.708380
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD miceDOI 10.64898/2026.02.26.708380
Deciphering Early and Progressive Molecular Signatures in Alzheimer’s Disease through Integrated Longitudinal Proteomic and Pathway Analysis in a Rodent ModelSemantic proximity
Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?Semantic proximity
Age-dependent brain proteome remodeling links <i>Abca7</i> deficiency to insulin signaling and neuroinflammation in Alzheimer’s disease miceSemantic proximity
Mitochondrial dysfunction in Alzheimer’s disease - a proteomics perspectiveSemantic proximity
Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer’s DiseaseSemantic proximity
Compilation of reported protein changes in the brain in Alzheimer’s diseaseSemantic proximity
Human-mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidomeSemantic proximity
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases.Semantic proximity
Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolismSemantic proximity
Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease.Semantic proximity
Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidomeSemantic proximity
Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb TreatmentSemantic proximity
Select a neighboring publication to make it the new centre.