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Diverse pathways to neuronal necroptosis in Alzheimer's disease

4 Apr 2022

Abstract excerpt

Necroptosis, or programmed necrosis, involves the kinase activity of receptor interacting kinases 1 and 3, the activation of the pseudokinase mixed lineage kinase domain-like and formation of a complex called the necrosome. It is one of the non-apoptotic cell death pathways that has gained interest in the recent years, especially as a neuronal cell death pathway occurring in Alzheimer's disease. In this review,...

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PMID: 35377966
DOI: 10.1111/ejn.15662

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